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Introduction

Section One

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Fig-1. Phenobarbital brain concentration versus time after a rapid bolus injection. Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity). Adapted from Paulson 1982^[1]

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Section Two

Group	Dose	Concentration	Conc:Dose Ratio
Tremulous (n=48)	8.5	14.0	1.65
Seizures (n=38)	8.3	13.8	1.66
Alcoholic liver disease (n=21)	8.2	13.7	1.67
TOTAL (n=62)	8.4	13.9	1.65

↑ Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190

[1] Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190

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 [[File:PB_CSF_pharmacokinetics_01.PNG|right|thumb|400px|'''Fig-1.  Phenobarbital brain concentration versus time after a rapid bolus injection'''.  Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity).  Adapted from Paulson 1982<ref>Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190</ref>]]
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+== Section Two ==
+{| class="wikitable"
+|-
+! scope="col"| Group
+! scope="col"| Dose
+! scope="col"| Concentration
+! scope="col"| Conc:Dose Ratio
+|-
+! scope="row"| Tremulous (n=48)
+| 8.5
+| 14.0
+| 1.65
+|-
+! scope="row"| Seizures (n=38)
+| 8.3
+| 13.8
+| 1.66
+|-
+! scope="row"| Alcoholic liver disease (n=21)
+| 8.2
+| 13.7
+| 1.67
+|-
+! scope="row"| TOTAL (n=62)
+| 8.4
+| 13.9
+| 1.65
+|}