From Guide to YKHC Medical Practices
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Section One

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Fig-1. Phenobarbital brain concentration versus time after a rapid bolus injection. Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity). Adapted from Paulson 1982[1]

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Section Two

Table-1. PB dose, concentration, and ratio for nonexclusive subgroups reported in Young (1987).[2]
Group Dose Concentration Conc:Dose Ratio
Tremulous (n=48) 8.5 14.0 1.65
Seizures (n=38) 8.3 13.8 1.66
Alcoholic liver disease (n=21) 8.2 13.7 1.67
ALL (n=62) 8.4 13.9 1.65
  1. Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190
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