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From Guide to YKHC Medical Practices

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[[File:PB_CSF_pharmacokinetics_01.PNG|right|thumb|500px|"Fig-1.  Phenobarbital brain concentration versus time after a rapid bolus injection.  Adapted from Paulson 1982."]]
[[File:PB_CSF_pharmacokinetics_01.PNG|right|thumb|400px|'''Fig-1.  Phenobarbital brain concentration versus time after a rapid bolus injection'''.  Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity).  Adapted from Paulson 1982<ref>Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190</ref>]]
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== Section Two ==
{| class="wikitable"
|+ style="caption-side:bottom;text-align:center;" |Table-1.  PB dose, concentration, and ratio for nonexclusive subgroups reported in Young (1987).<ref name = "young1987" />
|-
! scope="col"| Group
! scope="col"| Dose
! scope="col"| Concentration
! scope="col"| Conc:Dose Ratio
|-
| scope="row"| Tremulous (n=48)
| style="text-align:center;" | 8.5
| style="text-align:center;" | 14.0
| style="text-align:center;" | 1.65
|-
| scope="row"| Seizures (n=38)
| style="text-align:center;" | 8.3
| style="text-align:center;" | 13.8
| style="text-align:center;" | 1.66
|-
| scope="row"| Alcoholic liver disease (n=21)
| style="text-align:center;" | 8.2
| style="text-align:center;" | 13.7
| style="text-align:center;" | 1.67
|-
| scope="row"| ALL (n=62)
| style="text-align:center;" | 8.4
| style="text-align:center;" | 13.9
| style="text-align:center;" | 1.65
|}

Latest revision as of 18:32, 2 September 2019

Introduction

Section One

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Fig-1. Phenobarbital brain concentration versus time after a rapid bolus injection. Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity). Adapted from Paulson 1982[1]

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Section Two

Table-1. PB dose, concentration, and ratio for nonexclusive subgroups reported in Young (1987).[2]
Group Dose Concentration Conc:Dose Ratio
Tremulous (n=48) 8.5 14.0 1.65
Seizures (n=38) 8.3 13.8 1.66
Alcoholic liver disease (n=21) 8.2 13.7 1.67
ALL (n=62) 8.4 13.9 1.65
  1. Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190
  2. Cite error: Invalid <ref> tag; no text was provided for refs named young1987