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From Guide to YKHC Medical Practices
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[[File:PB_CSF_pharmacokinetics_01.PNG|right|thumb| | [[File:PB_CSF_pharmacokinetics_01.PNG|right|thumb|400px|'''Fig-1. Phenobarbital brain concentration versus time after a rapid bolus injection'''. Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity). Adapted from Paulson 1982<ref>Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190</ref>]] | ||
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== Section Two == | |||
{| class="wikitable" | |||
|+ style="caption-side:bottom;text-align:center;" |Table-1. PB dose, concentration, and ratio for nonexclusive subgroups reported in Young (1987).<ref name = "young1987" /> | |||
|- | |||
! scope="col"| Group | |||
! scope="col"| Dose | |||
! scope="col"| Concentration | |||
! scope="col"| Conc:Dose Ratio | |||
|- | |||
| scope="row"| Tremulous (n=48) | |||
| style="text-align:center;" | 8.5 | |||
| style="text-align:center;" | 14.0 | |||
| style="text-align:center;" | 1.65 | |||
|- | |||
| scope="row"| Seizures (n=38) | |||
| style="text-align:center;" | 8.3 | |||
| style="text-align:center;" | 13.8 | |||
| style="text-align:center;" | 1.66 | |||
|- | |||
| scope="row"| Alcoholic liver disease (n=21) | |||
| style="text-align:center;" | 8.2 | |||
| style="text-align:center;" | 13.7 | |||
| style="text-align:center;" | 1.67 | |||
|- | |||
| scope="row"| ALL (n=62) | |||
| style="text-align:center;" | 8.4 | |||
| style="text-align:center;" | 13.9 | |||
| style="text-align:center;" | 1.65 | |||
|} |
Latest revision as of 18:32, 2 September 2019
Introduction
Section One
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Section Two
Group | Dose | Concentration | Conc:Dose Ratio |
---|---|---|---|
Tremulous (n=48) | 8.5 | 14.0 | 1.65 |
Seizures (n=38) | 8.3 | 13.8 | 1.66 |
Alcoholic liver disease (n=21) | 8.2 | 13.7 | 1.67 |
ALL (n=62) | 8.4 | 13.9 | 1.65 |