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From Guide to YKHC Medical Practices
Introduction
Section One
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Fig-1. Phenobarbital brain concentration versus time after a rapid bolus injection. Y-axis is fractional concentration compared to the initial serum concentration (which has been removed for clarity). Adapted from Paulson 1982
[1]
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Section Two
Table-1. PB dose, concentration, and ratio for nonexclusive subgroups reported in Young (1987).[2]
Group
|
Dose
|
Concentration
|
Conc:Dose Ratio
|
Tremulous (n=48)
|
8.5
|
14.0
|
1.65
|
Seizures (n=38)
|
8.3
|
13.8
|
1.66
|
Alcoholic liver disease (n=21)
|
8.2
|
13.7
|
1.67
|
ALL (n=62)
|
8.4
|
13.9
|
1.65
|
- ↑ Paulson OB, Györy A, Hertz MM. Blood-brain barrier transfer and cerebral uptake of antiepileptic drugs. Clin Pharmacol Ther. 1982;32(4):466-477. doi:10.1038/clpt.1982.190
- ↑ Cite error: Invalid
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